Photolysis of Thiopurines in the Presence of Oxygen
نویسندگان
چکیده
Thiopurines, Photolysis, Photooxygenation, Purine Derivatives Irradiation (A > 290 nm) of 6-thiopurine and some 9-substituted 6-thiopurines in oxygen saturated iertf-butanol leads to hypoxanthine, purine and purine-6-sulfonic acid or their substituted derivatives. Purine and hypoxanthine formation can be sensitized with dyes. The reaction of 6-thiopurine with singlet oxygen has also been performed with purine and hypoxanthine among other products. It seems however that 02 is not an important intermediate in the photooxygenation. The photoreaction may have some synthetic value. Hypoxanthines ( ~ 5 0 % ) or purines (35-45%) were obtained depending on the solvent used.
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